What is the maximum total dose of amiodarone allowed in pediatric VT/VF arrest?

What is the maximum total dose of amiodarone allowed in pediatric VT/VF arrest?

• A. 10 mg/kg total
• B. 15 mg/kg total
• C. 20 mg/kg total
• D. 5 mg/kg total

Answer: (B)

In pediatric VT/VF arrest, amiodarone is used after defibrillation attempts fail to suppress the persistent rhythm, to help restore a stable rhythm during CPR. The dosing is 5 mg/kg given as an IV or IO bolus, and this can be repeated, up to a total of 15 mg/kg during that arrest. For example, a child weighing 20 kg would receive 100 mg per bolus, with up to three boluses for a cumulative total of 300 mg. The reason for the 15 mg/kg cap is to balance the antiarrhythmic benefit with safety, since higher cumulative doses increase the risk of adverse effects like hypotension and bradycardia. If VT/VF persists after two additional doses, continue CPR and defibrillation as indicated and reassess the plan.

In pediatric VT/VF arrest, amiodarone is used after defibrillation attempts fail to suppress the persistent rhythm, to help restore a stable rhythm during CPR. The dosing is 5 mg/kg given as an IV or IO bolus, and this can be repeated, up to a total of 15 mg/kg during that arrest. For example, a child weighing 20 kg would receive 100 mg per bolus, with up to three boluses for a cumulative total of 300 mg. The reason for the 15 mg/kg cap is to balance the antiarrhythmic benefit with safety, since higher cumulative doses increase the risk of adverse effects like hypotension and bradycardia. If VT/VF persists after two additional doses, continue CPR and defibrillation as indicated and reassess the plan.